Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC050
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-02 10:32
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment New patient

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 7, 'TN': 8, 'TP': 35, 'FP': 22}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 39, 'TN': 27, 'TP': 3, 'FP': 3}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 19, 'TN': 9, 'TP': 23, 'FP': 21}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 10.124
timePerCircleCoV 0.15765
timePerCircleSlope -0.0345055
meanError 1.86784
tremorFreq 4.88281
tremorRelPower 85.7573
tremorGyroAmpMean 0.164599
tremorGyroAmpSlope 0.00254538
tremorGyroAmpCoV 0.485183
tremorCoordAmpMean 0.425326
tremorCoordAmpSlope 0.00182463
tremorCoordAmpCoV 0.265626
tremorAccAmpMean 0.420407
tremorAccAmpSlope 0.00468571
tremorAccAmpCoV 0.270492
tremorPcRelVar 0.911446
tremorPcX 0.40374
tremorPcY 0.914874

Circle Segment 1

Duration 11.68 s, Accuracy Estimate 2.393 (lower is better)

Circle Segment 2

Duration 13.92 s, Accuracy Estimate 1.794 (lower is better)

Circle Segment 3

Duration 10.2 s, Accuracy Estimate 1.472 (lower is better)

Circle Segment 4

Duration 9.0 s, Accuracy Estimate 1.916 (lower is better)

Circle Segment 5

Duration 9.04 s, Accuracy Estimate 1.606 (lower is better)

Circle Segment 6

Duration 9.68 s, Accuracy Estimate 1.52 (lower is better)

Circle Segment 7

Duration 9.92 s, Accuracy Estimate 1.77 (lower is better)

Circle Segment 8

Duration 10.12 s, Accuracy Estimate 1.579 (lower is better)

Circle Segment 9

Duration 8.6 s, Accuracy Estimate 1.642 (lower is better)

Circle Segment 10

Duration 9.08 s, Accuracy Estimate 2.987 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 28.548
timePerSpiralCoV 0.121978
timePerSpiralSlope -0.0346381
meanError 2.27995
tremorFreq 5.37109
tremorRelPower 75.487
tremorGyroAmpMean 0.140793
tremorGyroAmpSlope 0.000510068
tremorGyroAmpCoV 0.374398
tremorCoordAmpMean 0.285484
tremorCoordAmpSlope -2.05379e-05
tremorCoordAmpCoV 0.291435
tremorAccAmpMean 0.241958
tremorAccAmpSlope -1.98989e-05
tremorAccAmpCoV 0.318981
tremorPcRelVar 0.751271
tremorPcX 0.677133
tremorPcY -0.73586

Spiral Segment 1

Duration 32.84 s, Accuracy Estimate 2.185 (lower is better)

Spiral Segment 2

Duration 33.08 s, Accuracy Estimate 2.109 (lower is better)

Spiral Segment 3

Duration 29.12 s, Accuracy Estimate 2.113 (lower is better)

Spiral Segment 4

Duration 28.96 s, Accuracy Estimate 2.38 (lower is better)

Spiral Segment 5

Duration 28.68 s, Accuracy Estimate 2.274 (lower is better)

Spiral Segment 6

Duration 31.52 s, Accuracy Estimate 2.306 (lower is better)

Spiral Segment 7

Duration 28.64 s, Accuracy Estimate 2.52 (lower is better)

Spiral Segment 8

Duration 23.56 s, Accuracy Estimate 2.485 (lower is better)

Spiral Segment 9

Duration 25.92 s, Accuracy Estimate 2.214 (lower is better)

Spiral Segment 10

Duration 23.16 s, Accuracy Estimate 2.214 (lower is better)

Elel

eDurationMean 0.577821
eDurationStd 0.115979
eDurationStdnorm 0.200717
eDurationMedian 0.555
eDurationQuartdelta 0.15875
eDurationQuartdeltanorm 0.286036
eDurationKurt 2.79049
eDurationTrenddiff -0.145
eDurationTrendratio 0.771654
eWidthMean 5.367
eWidthStd 1.75709
eWidthStdnorm 0.327387
eWidthMedian 5.148
eWidthQuartdelta 2.6325
eWidthQuartdeltanorm 0.511364
eWidthKurt 2.39297
eWidthTrenddiff 0.234
eWidthTrendratio 1.04762
eHeightMean 9.741
eHeightStd 2.23217
eHeightStdnorm 0.229152
eHeightMedian 9.36
eHeightQuartdelta 2.31075
eHeightQuartdeltanorm 0.246875
eHeightKurt 3.22694
eHeightTrenddiff -1.053
eHeightTrendratio 0.891566
eAspectMean 0.54686
eAspectStd 0.104412
eAspectStdnorm 0.19093
eAspectMedian 0.564103
eAspectQuartdelta 0.12343
eAspectQuartdeltanorm 0.218808
eAspectKurt 2.78595
eAspectTrenddiff 0.0853281
eAspectTrendratio 1.1726
eSlantMean -0.0628165
eSlantStd 0.191019
eSlantStdnorm -3.04091
eSlantMedian -0.0434783
eSlantQuartdelta 0.265827
eSlantQuartdeltanorm -6.11403
eSlantKurt 2.65943
eSlantTrenddiff 0.0462653
eRtopMean 0.71856
eRtopStd 0.17566
eRtopStdnorm 0.244462
eRtopMedian 0.74026
eRtopQuartdelta 0.239354
eRtopQuartdeltanorm 0.323337
eRtopKurt 2.32339
eRtopTrenddiff 0.0191142
eRbotMean 0.869788
eRbotStd 0.277377
eRbotStdnorm 0.318902
eRbotMedian 0.857143
eRbotQuartdelta 0.355399
eRbotQuartdeltanorm 0.414632
eRbotKurt 2.84163
eRbotTrenddiff 0.0285714
eRrightMean 0.834345
eRrightStd 0.125788
eRrightStdnorm 0.150762
eRrightMedian 0.860465
eRrightQuartdelta 0.197828
eRrightQuartdeltanorm 0.229909
eRrightKurt 2.28397
eRrightTrenddiff 0.0201319
eRleftMean 0.412693
eRleftStd 0.108169
eRleftStdnorm 0.262105
eRleftMedian 0.396396
eRleftQuartdelta 0.137839
eRleftQuartdeltanorm 0.347731
eRleftKurt 2.51355
eRleftTrenddiff -0.0540584
lDurationMean 0.838415
lDurationStd 0.251608
lDurationStdnorm 0.3001
lDurationMedian 0.745
lDurationQuartdelta 0.225
lDurationQuartdeltanorm 0.302013
lDurationKurt 4.77838
lDurationTrenddiff -0.215
lDurationTrendratio 0.763085
lWidthMean 9.83085
lWidthStd 1.55096
lWidthStdnorm 0.157765
lWidthMedian 9.711
lWidthQuartdelta 2.25225
lWidthQuartdeltanorm 0.231928
lWidthKurt 2.63431
lWidthTrenddiff 0.7605
lWidthTrendratio 1.08125
lHeightMean 23.4799
lHeightStd 4.15527
lHeightStdnorm 0.176971
lHeightMedian 22.815
lHeightQuartdelta 6.201
lHeightQuartdeltanorm 0.271795
lHeightKurt 2.41843
lHeightTrenddiff -4.797
lHeightTrendratio 0.813636
lAspectMean 0.428161
lAspectStd 0.0834866
lAspectStdnorm 0.194989
lAspectMedian 0.42
lAspectQuartdelta 0.134726
lAspectQuartdeltanorm 0.320775
lAspectKurt 2.02049
lAspectTrenddiff 0.124055
lAspectTrendratio 1.34384
lSlantMean 0.0881155
lSlantStd 0.0972598
lSlantStdnorm 1.10378
lSlantMedian 0.0684211
lSlantQuartdelta 0.0990557
lSlantQuartdeltanorm 1.44774
lSlantKurt 4.2785
lSlantTrenddiff 0.0828748
lRtopMean 0.822123
lRtopStd 0.088243
lRtopStdnorm 0.107335
lRtopMedian 0.820513
lRtopQuartdelta 0.109724
lRtopQuartdeltanorm 0.133727
lRtopKurt 3.14625
lRtopTrenddiff 0.065042
lRbotMean 0.633525
lRbotStd 0.184365
lRbotStdnorm 0.291015
lRbotMedian 0.6375
lRbotQuartdelta 0.23063
lRbotQuartdeltanorm 0.361773
lRbotKurt 3.68667
lRbotTrenddiff -0.151248
lRrightMean 0.870393
lRrightStd 0.0883593
lRrightStdnorm 0.101517
lRrightMedian 0.891429
lRrightQuartdelta 0.101865
lRrightQuartdeltanorm 0.114271
lRrightKurt 6.46254
lRrightTrenddiff 0.034491
lRleftMean 0.321687
lRleftStd 0.121551
lRleftStdnorm 0.377854
lRleftMedian 0.315789
lRleftQuartdelta 0.159087
lRleftQuartdeltanorm 0.503775
lRleftKurt 3.89518
lRleftTrenddiff -0.114313

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.929971
sumTouchScores 26.0392
meanMovementTime 0.684444
numTouches 28
undershootPercentage 7.14286
overshootPercentage 0

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.860068
sumTouchScores 17.2014
meanMovementTime 0.973421
numTouches 20
undershootPercentage 5
overshootPercentage 5

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 15.176
timePerZigzagCoV 0.159703
timePerZigzagSlope -0.0263574
meanError 3.47825
tremorFreq 6.15234
tremorRelPower 27.4546
tremorGyroAmpMean 0.1251
tremorGyroAmpSlope -4.36529e-05
tremorGyroAmpCoV 0.312272
tremorCoordAmpMean 0.273411
tremorCoordAmpSlope 0.00245882
tremorCoordAmpCoV 0.258283
tremorAccAmpMean 0.263499
tremorAccAmpSlope 0.00241088
tremorAccAmpCoV 0.231261
tremorPcRelVar 0.764561
tremorPcX 0.864654
tremorPcY -0.502367

ZigZag Segment 1

Duration 17.12 s, Accuracy Estimate 3.761 (lower is better)

ZigZag Segment 2

Duration 12.6 s, Accuracy Estimate 3.898 (lower is better)

ZigZag Segment 3

Duration 18.16 s, Accuracy Estimate 3.102 (lower is better)

ZigZag Segment 4

Duration 13.16 s, Accuracy Estimate 3.099 (lower is better)

ZigZag Segment 5

Duration 14.84 s, Accuracy Estimate 3.532 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.648
timePerZigzagCoV 0.261025
timePerZigzagSlope -0.123656
zigzagHeightMean 65.0017
zigzagHeightCoV 0.086226
zigzagHeightSlope -0.0520353
meanError 0.0453448
tremorFreq 5.95703
tremorRelPower 23.1667
tremorGyroAmpMean 0.121379
tremorGyroAmpSlope -0.0043978
tremorGyroAmpCoV 0.272727
tremorCoordAmpMean 0.350424
tremorCoordAmpSlope -0.00293914
tremorCoordAmpCoV 0.246595
tremorAccAmpMean 0.317787
tremorAccAmpSlope -0.0017184
tremorAccAmpCoV 0.213424
tremorPcRelVar 0.614545
tremorPcX 0.671623
tremorPcY -0.740893

ZigZag Offset Segment 1

Duration 18.32 s, Accuracy Estimate 0.083 (lower is better)

ZigZag Offset Segment 2

Duration 11.52 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 3

Duration 10.88 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 4

Duration 12.52 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 5

Duration 10.0 s, Accuracy Estimate 0.045 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.74}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.5842025778200648}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8927640654006177}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6672511569026484}